Abstract

BACKGROUND/AIMS
Dietary pattern and genetic predisposition of each population have different impacts on lifestyle-related chronic diseases. This study was conducted to evaluate the association and interaction between dietary patterns and VEGFR2 or KDR gene polymorphisms on physical and biochemical risk factors of cardiovascular disease in two Asian populations (179 Chinese Malaysian and 136 Japanese adults).
METHODS
Dietary patterns were constructed from food frequency questionnaire using factor analysis. Genotyping of rs1870377 and rs2071559 was performed by real-time PCR using TaqMan probes. Physical measurements: body mass index, systolic and diastolic blood pressures and biochemical parameters: glycated hemoglobin A1c and blood lipids (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol and total cholesterol/HDL-C ratio) were measured.
RESULTS
Two dietary patterns were extracted for: Japanese ('Japanese diet' and 'Western diet') and Chinese Malaysians ('Balanced diet'; and 'Meat, rice and noodles diet'). In Japanese, 'Western Diet' and rs2071559 were associated with LDL-C and HDL-C, respectively. In Chinese Malaysians, 'Meat, rice and noodles diet' was asso-ciated with triglycerides, HDL-C and total cholesterol/HDL ratio while rs1870377 and rs2071559 were associated with total cholesterol and/or LDL-C. The interaction between 'Western Diet' and rs2071559 in Japanese and 'Meat, rice and noodles diet' and rs1870377 in Malaysians had significant effects on blood lipids after adjusting for confounders.
CONCLUSIONS
The association and interaction of dietary patterns and VEGFR2 gene polymorphisms on blood lipids differ between Chinese Malaysian and Japanese subjects by either decreasing or increasing the risk of cardiovascular disease.

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Authors

Yap RW, Shidoji Y, Hon WM, Masaki M

Institution

University of Nagasaki, Nagayo, Nagasaki, Japan.

Source

Asia Pacific journal of clinical nutrition 21:2 2012 pg 302-11

MeSH

Adult
Aged
Cardiovascular Diseases
China
Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies
Diet
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Hypercholesterolemia
Japan
Malaysia
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Vascular Endothelial Growth Factor Receptor-2

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22507619