Abstract

Curcumin was solubilized by Pluronics and the concentration of dissolved curcumin seemed to be related to the number of propylene oxide units in the Pluronic polymer. All Pluronics showed a maximum solubilizing capacity at a certain curcumin: Pluronic molar ratio and exceeding this molar ratio resulted in precipitation of curcumin when following the samples for 356 hours. PEG 400 could to a certain extent stabilize the supersaturated samples, while ethanol physically destabilized the samples. Ionic strength did not influence the solubilization of curcumin by the Pluronics. Supersaturation and precipitation inhibition caused a higher concentration of curcumin in samples prepared by SEM compared to samples prepared by SFM (i.e. the thermodynamic solubility).

Links

Publisher Full Text

Authors

Singh R, Kristensen S, Tønnesen HH

Institution

School of Pharmacy, Department of Pharmaceutics, University of Oslo, Blindern, Norway. ravindersingh@farmasi.uio.no

Source

Die Pharmazie 67:2 2012 Feb pg 131-42

MeSH

Adsorption
Calibration
Calorimetry, Differential Scanning
Chromatography, High Pressure Liquid
Curcumin
Micelles
Microscopy, Electron, Scanning
Molecular Weight
Osmolar Concentration
Poloxamer
Reference Standards
Reproducibility of Results
Solubility
Solvents
Specimen Handling
gamma-Cyclodextrins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22512083