Unbound MEDLINE

Influence of cosolvents, ionic strength and the method of sample preparation on the solubilization of curcumin by Pluronics and HP-gamma-cyclodextrin. Studies of curcumin and curcuminoids, XLIV.

Abstract

Curcumin was solubilized by Pluronics and the concentration of dissolved curcumin seemed to be related to the number of propylene oxide units in the Pluronic polymer. All Pluronics showed a maximum solubilizing capacity at a certain curcumin: Pluronic molar ratio and exceeding this molar ratio resulted in precipitation of curcumin when following the samples for 356 hours. PEG 400 could to a certain extent stabilize the supersaturated samples, while ethanol physically destabilized the samples. Ionic strength did not influence the solubilization of curcumin by the Pluronics. Supersaturation and precipitation inhibition caused a higher concentration of curcumin in samples prepared by SEM compared to samples prepared by SFM (i.e. the thermodynamic solubility).

Links

  • Publisher Full Text
  • Authors

    Singh R, Kristensen S, Tønnesen HH

    Source

    Die Pharmazie 67:2 2012 Feb pg 131-42

    MeSH

    Adsorption
    Calibration
    Calorimetry, Differential Scanning
    Chromatography, High Pressure Liquid
    Curcumin
    Micelles
    Microscopy, Electron, Scanning
    Molecular Weight
    Osmolar Concentration
    Poloxamer
    Reference Standards
    Reproducibility of Results
    Solubility
    Solvents
    Specimen Handling
    gamma-Cyclodextrins

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22512083