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Correlation of brain natriuretic peptide and microalbuminuria in patients with heart failure.

Abstract

OBJECTIVE
To evaluate the changes of plasma levels of N-terminal pro-brain natriuretic pepide (NT-proBNP) and microalbuminuria (MAU) in patients with heart failure and the correlation between them.
METHODS
Ninety-one patients with heart failure were divided into different groups according to different stages of heart failure. Plasma levels of NT-proBNP were measured by microsome enzyme immunoassay (MEIA). Plasma levels of MAU were determined by immune scattering turbidimetry (ICTM). Simultaneously, left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD) were measured by Doppler echocardiography for all patients. The correlation of NT-proBNP and MAU was evaluated at different stages of heart failure.
RESULTS
The plasma levels of NT-proBNP and MAU increased with the severity of heart failure. There was a high correlation between NT-proBNP and MAU (r = 0.885, p < 0.001).
CONCLUSION
Both NT-proBNP and MAU levels were closely associated with the severity of heart failure.

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  • Aggregator Full Text
  • Authors

    Peng T, Gao H, Shen L, Xu F, Yang X

    Source

    The West Indian medical journal 60:6 2011 Dec pg 658-61

    MeSH

    Aged
    Albuminuria
    Analysis of Variance
    Biological Markers
    Echocardiography, Doppler
    Female
    Heart Failure
    Heart Function Tests
    Humans
    Immunoenzyme Techniques
    Linear Models
    Male
    Middle Aged
    Natriuretic Peptide, Brain
    Nephelometry and Turbidimetry
    Severity of Illness Index

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22512224