Abstract

OBJECTIVE
To evaluate the changes of plasma levels of N-terminal pro-brain natriuretic pepide (NT-proBNP) and microalbuminuria (MAU) in patients with heart failure and the correlation between them.
METHODS
Ninety-one patients with heart failure were divided into different groups according to different stages of heart failure. Plasma levels of NT-proBNP were measured by microsome enzyme immunoassay (MEIA). Plasma levels of MAU were determined by immune scattering turbidimetry (ICTM). Simultaneously, left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD) were measured by Doppler echocardiography for all patients. The correlation of NT-proBNP and MAU was evaluated at different stages of heart failure.
RESULTS
The plasma levels of NT-proBNP and MAU increased with the severity of heart failure. There was a high correlation between NT-proBNP and MAU (r = 0.885, p < 0.001).
CONCLUSION
Both NT-proBNP and MAU levels were closely associated with the severity of heart failure.

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Authors

Peng T, Gao H, Shen L, Xu F, Yang X

Institution

Department of Nephrology, Shandong University Qilu Hospital, Jinan, China.

Source

The West Indian medical journal 60:6 2011 Dec pg 658-61

MeSH

Aged
Albuminuria
Analysis of Variance
Biological Markers
Echocardiography, Doppler
Female
Heart Failure
Heart Function Tests
Humans
Immunoenzyme Techniques
Linear Models
Male
Middle Aged
Natriuretic Peptide, Brain
Nephelometry and Turbidimetry
Severity of Illness Index

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22512224