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Correlation of brain natriuretic peptide and microalbuminuria in patients with heart failure.
OBJECTIVETo evaluate the changes of plasma levels of N-terminal pro-brain natriuretic pepide (NT-proBNP) and microalbuminuria (MAU) in patients with heart failure and the correlation between them.
METHODSNinety-one patients with heart failure were divided into different groups according to different stages of heart failure. Plasma levels of NT-proBNP were measured by microsome enzyme immunoassay (MEIA). Plasma levels of MAU were determined by immune scattering turbidimetry (ICTM). Simultaneously, left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD) were measured by Doppler echocardiography for all patients. The correlation of NT-proBNP and MAU was evaluated at different stages of heart failure.
RESULTSThe plasma levels of NT-proBNP and MAU increased with the severity of heart failure. There was a high correlation between NT-proBNP and MAU (r = 0.885, p < 0.001).
CONCLUSIONBoth NT-proBNP and MAU levels were closely associated with the severity of heart failure.
The West Indian medical journal 60:6 2011 Dec pg 658-61
Analysis of Variance
Heart Function Tests
Natriuretic Peptide, Brain
Nephelometry and Turbidimetry
Severity of Illness Index
Pub Type(s)Journal Article