Abstract

Rat Everted Gut Sac (EGS) model was employed to study the intestinal uptake of titanium and iron. Incubation of freshly prepared rat EGS in Earle's medium pH = 7.4 containing titanium showed that the absorption of titanium as well as iron was a dose dependent process. Ascorbic acid enhanced the absorption of both metal ions, while NaF (1 mM) as an inhibitor of glycolytic energy supply, decreased their absorption. The Na+-K+ ATPase inhibitor, ouabain (1 mM) reduced intestinal absorption of Titanium. This suggests that titanium uptake is an active transport process as is iron uptake. Iron absorption was reduced approximate by 17% when titanium was presented to incubation medium EGS whereas, the absorption of titanium was decreased by 35% when iron was added to the reaction mixture.

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Authors

Aarabi MH, Moshtaghie AA, Mirhashemi M

Institution

Department of Biochemistry, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Source

Pakistan journal of biological sciences: PJBS 14:20 2011 Oct 15 pg 945-9

MeSH

Animals
Ascorbic Acid
Biological Transport
Biological Transport, Active
Citric Acid
Intestinal Absorption
Intestinal Mucosa
Iron Compounds
Male
Ouabain
Rats
Rats, Wistar
Sodium Fluoride
Sodium-Potassium-Exchanging ATPase
Titanium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22514896