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Comparative in vitro study of the intestinal absorption of titanium and iron in rats.

Abstract

Rat Everted Gut Sac (EGS) model was employed to study the intestinal uptake of titanium and iron. Incubation of freshly prepared rat EGS in Earle's medium pH = 7.4 containing titanium showed that the absorption of titanium as well as iron was a dose dependent process. Ascorbic acid enhanced the absorption of both metal ions, while NaF (1 mM) as an inhibitor of glycolytic energy supply, decreased their absorption. The Na+-K+ ATPase inhibitor, ouabain (1 mM) reduced intestinal absorption of Titanium. This suggests that titanium uptake is an active transport process as is iron uptake. Iron absorption was reduced approximate by 17% when titanium was presented to incubation medium EGS whereas, the absorption of titanium was decreased by 35% when iron was added to the reaction mixture.

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  • Authors

    Aarabi MH, Moshtaghie AA, Mirhashemi M

    Institution

    Department of Biochemistry, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

    Source

    Pakistan journal of biological sciences: PJBS 14:20 2011 Oct 15 pg 945-9

    MeSH

    Animals
    Ascorbic Acid
    Biological Transport
    Biological Transport, Active
    Citric Acid
    Intestinal Absorption
    Intestinal Mucosa
    Iron Compounds
    Male
    Ouabain
    Rats
    Rats, Wistar
    Sodium Fluoride
    Sodium-Potassium-Exchanging ATPase
    Titanium

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22514896