Unbound MEDLINE

Determination of ferritin and hemosiderin iron in patients with normal iron stores and iron overload by serum ferritin kinetics.

Abstract

We attempted to clarify the storage iron metabolism from the change in the serum ferritin level. We assumed that the nonlinear decrease in serum ferritin was caused by serum ferritin increase in iron mobilization. Under this assumption, we determined both ferritin and hemosiderin iron levels by computer-assisted simulation of the row of decreasing assay-dots of serum ferritin in 11 patients with normal iron stores free of both iron deficiency and iron overload; chronic hepatitis C (CHC) and iron deficiency anemia after treatment, and 11 patients with iron overload; hereditary hemochromatosis (HH) and transfusion-dependent anemias (TD). We determined the iron removal rates of 20 and 17 mg/day by administering mean doses of deferasirox at 631 and 616 mg/day in 2 TD during the period of balance of iron addition and removal as indicated by the serum ferritin returned to the previous level. The ferritin-per-hemosiderin ratio was almost the same in both HH and CHC. This matched the localized hepatic hemosiderin deposition in CHC with normal iron stores. We detected the ferritin increased by utilizing the hemosiderin iron in iron removal and the ferritin reduced by transforming ferritin into hemosiderin in iron additions. The iron storing capacity of hemosiderin was limitless, while that of ferritin was suppressed when ferritin iron exceeded around 5 grams. We confirmed the pathway of iron from hemosiderin to ferritin in iron mobilization, and that from ferritin to hemosiderin in iron deposition. Thus, serum ferritin kinetics enabled us to be the first to clinically clarify storage iron metabolism.

Authors

Saito H, Tomita A, Ohashi H, Maeda H, Hayashi H, Naoe T

Source

Nagoya journal of medical science 74:1-2 2012 Feb pg 39-49

MeSH

Anemia
Benzoates
Biological Markers
Computer Simulation
Female
Ferritins
Hemochromatosis
Hemosiderin
Hepatitis C, Chronic
Humans
Iron
Iron Chelating Agents
Iron Overload
Japan
Kinetics
Liver
Male
Middle Aged
Models, Biological
Triazoles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22515110