Unbound MEDLINE

Next-generation regeneration: the hope and hype of lung stem cell research.

Abstract

Research discoveries in the fields of stem cell biology and regenerative medicine are beginning to advance and refine our understanding of lung injury and repair. Although these emerging studies offer unprecedented opportunities to develop novel therapies for a variety of lung diseases, the quickening pace of work in this nascent field also makes it difficult to discern hope from hype when addressing the pleas of patients eager for clinical translation or when seeking information on the risk versus reward of participation in clinical trials. This perspective provides an overview of the latest advances in lung-related stem cell research and places the new discoveries in a historical context. Established, lineage-restricted epithelial progenitors of the conducting airways and gas-exchanging alveoli are briefly reviewed, and controversial, newly proposed tissue-specific candidate lung stem/progenitor cells with broader differentiation repertoire are introduced. Exogenous derivation of lung epithelia from embryonic stem cells or induced pluripotent stem cells is also presented as an alternative method for engineering lung tissue de novo in culture.

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  • Publisher Full Text
  • Authors

    Kotton DN

    Source

    American journal of respiratory and critical care medicine 185:12 2012 Jun 15 pg 1255-60

    MeSH

    Clinical Trials, Phase I as Topic
    Clinical Trials, Phase II as Topic
    Female
    Follow-Up Studies
    Forecasting
    Graft Survival
    Humans
    Induced Pluripotent Stem Cells
    Lung Diseases
    Male
    Regeneration
    Regenerative Medicine
    Risk Assessment
    Stem Cell Research
    Stem Cell Transplantation
    Tissue Engineering

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22517787