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Evaluation of leptin levels among fibromyalgia patients before and after three months of treatment, in comparison with healthy controls.

Abstract

BACKGROUND
Leptin, an adipocyte-produced cytokine, interacts with various hormones, including those of the hypothalamic-pituitary-adrenal axis. Fibromyalgia is a syndrome characterized by widespread pain accompanied by tenderness. The pathogenesis involves a disturbance in pain processing and transmission by the central nervous system, leading to a general increase in pain perception.
OBJECTIVES
To analyze potential changes in leptin levels among female fibromyalgia patients compared with healthy controls, and to evaluate the changes in leptin levels during treatment.
METHODS
Sixteen female fibromyalgia patients were recruited. Patients underwent clinical evaluation, physical examination, including manual dolorimetry, and were evaluated regarding quality of life, pain, fatigue, anxiety and depression. Plasma leptin levels were determined by ELISA. Patients were offered standard treatment for fibromyalgia. Clinical evaluation and leptin determination were repeated after three months.
RESULTS
No significant difference was observed between leptin levels among fibromyalgia patients and controls; no significant correlation was observed between leptin levels and clinical parameters reflecting fibromyalgia severity; and no significant change was observed in leptin levels over three months of treatment. These results did not change after adjustment of leptin levels for body mass index values.
CONCLUSIONS
The results of the present study do not support the existence of a significant relationship between leptin and fibromyalgia pathogenesis. Increasing the sample size or examining the interaction between leptin and additional hormones⁄mediators of metabolism and body weight control may yet uncover significant information in this field.

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  • Publisher Full Text
  • Authors

    Ablin JN, Aronov N, Shimon I, Kanety H, Pariente C, Aloush V, Elkayam O, Levartovsky D

    Institution

    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. ajacob@post.tau.ac.il

    Source

    Pain research & management : the journal of the Canadian Pain Society = journal de la société canadienne pour le traitement de la douleur 17:2 pg 89-92

    MeSH

    Acetaminophen
    Adult
    Analgesics
    Analgesics, Non-Narcotic
    Antidepressive Agents, Tricyclic
    Body Mass Index
    Body Weight
    Female
    Fibromyalgia
    Health Surveys
    Humans
    Leptin
    Middle Aged
    Musculoskeletal Pain
    Pain Threshold
    Serotonin Uptake Inhibitors

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    22518370