Abstract

OBJECTIVE
To determine whether ovarian stimulation outcome and success rates are equivalent between GnRH agonist and GnRH antagonist regimens when all other variables are held constant.
STUDY DESIGN
Retrospective analysis. Infertile patients (n = 1,277) < 35 years of age, with normal ovarian reserve, undergoing their first in vitro fertilization cycle with a GnRH antagonist or agonist were included. Outcome variables were analyzed and compared between both groups.
RESULTS
Of the total number of patients included, 21% (n = 268) underwent stimulation with a GnRH antagonist protocol and 79% (n = 1,009) with an agonist protocol. While the mean number of embryos transferred was similar between both groups, as well as the implantation rate for blastocyst embryo transfers, the implantation rate was noted to be slightly higher for the down-regulation group who underwent a Day 3 embryo transfer (p = 0.01). However, the overall clinical pregnancy, loss and high-order multiple pregnancy rates were constant in both groups.
CONCLUSION
Although numerous variables were analyzed in our study, the differences noted did not have an impact on our final results as the clinical pregnancy rates were maintained in the antagonist group.

Authors

Luna M, Vela G, McDonald CA, Copperman AB

Institution

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10022, USA.

Source

The Journal of reproductive medicine 57:3-4 pg 123-8

MeSH

Adult
Case-Control Studies
Drug Administration Schedule
Embryo Transfer
Female
Fertility Agents, Female
Gonadotropin-Releasing Hormone
Humans
Injections, Intramuscular
New York City
Ovulation Induction
Pregnancy
Pregnancy Outcome
Retrospective Studies

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22523871