Does assisted reproductive technology itself or polycystic ovary syndrome as a cause of infertility have any effect on first trimester serum screening results?
To determine whether assisted reproductive technology (ART) itself or polycystic ovary syndrome (PCOS) as a cause of infertility has any effect on first trimester serum screening results.
First trimester serum screening results of ART pregnancies of women with PCOS (IVF-P group) were compared with those of women who underwent ART due to malefactor infertility (IVF-H group) and women who conceived spontaneously.
Comparison of the groups for crown-rump length (CRL) and nuchal translucency revealed no significance. There was significant difference between the IVF-H and IVF-P groups in terms of free beta-human chorionic gonadotropin (beta-hCG) levels. Although comparison of groups revealed no significance, pregnancy-associated plasma protein A (PAPP-A) values were higher in the IVF-P group than in the IVF-H group.
CRL and nuchal translucency measurements were not affected by in vitro fertilization procedures or the presence of maternal PCOS. Use of ART decreased PAPP-A and increased free beta-hCG levels. Although not significant, PAPP-A was higher in PCOS patients who conceived with ART, which may in turn increase false negative rates in these cases.
Department of Obstetrics and Gynecology, Fatih University, Faculty of Medicine, Ankara, Turkey.
SourceThe Journal of reproductive medicine 57:3-4 pg 129-35
Chorionic Gonadotropin, beta Subunit, Human
Polycystic Ovary Syndrome
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A
Reproductive Techniques, Assisted
Pub Type(s)Journal Article