Unbound MEDLINE

Lycopene ameliorates erectile dysfunction in streptozotocin-induced diabetic rats.

Abstract

Diabetes mellitus (DM) is characterized by oxidative stress, which is one of the major pathophysiological mechanisms underlying diabetic erectile dysfunction (ED). Lycopene is one of the most potent antioxidants among the natural carotenoids. The present study was aimed to investigate whether lycopene could lower oxidative stress and attenuate ED in diabetic rats. Lycopene (10, 30, 60 mg/kg/d) was administered via intragastric intubation for 8 weeks to streptozotocin (STZ) (50 mg/kg, i.v.) induced diabetic rats. The results showed that chronic lycopene treatment significantly and dose dependently restored ED in diabetic rats by lowering blood glucose, reducing oxidative stress and up-regulating eNOS expression. These results indicated that lycopene treatment is potentially a new strategy for treating diabetic ED.

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  • Publisher Full Text
  • Authors

    Gao JX, Li Y, Zhang HY, He XL, Bai AS

    Source

    Die Pharmazie 67:3 2012 Mar pg 256-9

    MeSH

    Animals
    Antioxidants
    Blood Glucose
    Blood Pressure
    Blotting, Western
    Body Weight
    Carotenoids
    Diabetes Mellitus, Experimental
    Erectile Dysfunction
    Male
    Malondialdehyde
    Nitric Oxide Synthase Type III
    Oxidative Stress
    Penis
    Rats
    Rats, Sprague-Dawley
    Real-Time Polymerase Chain Reaction
    Regional Blood Flow
    Superoxide Dismutase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22530309