Lycopene ameliorates erectile dysfunction in streptozotocin-induced diabetic rats.
Diabetes mellitus (DM) is characterized by oxidative stress, which is one of the major pathophysiological mechanisms underlying diabetic erectile dysfunction (ED). Lycopene is one of the most potent antioxidants among the natural carotenoids. The present study was aimed to investigate whether lycopene could lower oxidative stress and attenuate ED in diabetic rats. Lycopene (10, 30, 60 mg/kg/d) was administered via intragastric intubation for 8 weeks to streptozotocin (STZ) (50 mg/kg, i.v.) induced diabetic rats. The results showed that chronic lycopene treatment significantly and dose dependently restored ED in diabetic rats by lowering blood glucose, reducing oxidative stress and up-regulating eNOS expression. These results indicated that lycopene treatment is potentially a new strategy for treating diabetic ED.
Department of Urology, Yanan University Affiliated Hospital, Yanan University, Yanan, PR China.
SourceDie Pharmazie 67:3 2012 Mar pg 256-9
Diabetes Mellitus, Experimental
Nitric Oxide Synthase Type III
Real-Time Polymerase Chain Reaction
Regional Blood Flow
Pub Type(s)Journal Article