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Effects of an aqueous extract of Orbignya phalerata Mart on locomotor activity and motor coordination in mice and as antioxidant in vitro.

Abstract

The antioxidant activities of aqueous extract (AE) of Orbignya phalerata were assessed in vitro as well as its effect on locomotor activity and motor coordination in mice. AE does not possesses a strong antioxidant potential according to the scavenging assays; it also did not present scavenger activity in vitro. Following oral administration, AE (1, 2 and 3 g/kg) did not significantly change the motor activity of animals when compared with the control group, up to 24 h after administration and did not alter the remaining time of the animals on the Rota-rod apparatus. Further studies currently in progress will enable us to understand the mechanisms of action of the aqueous extract of Orbignya phalerata widely used in Brazilian flok medicine.

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  • Publisher Full Text
  • Authors

    Silva AP, Cerqueira GS, Nunes LC, de Freitas RM

    Source

    Die Pharmazie 67:3 2012 Mar pg 260-3

    MeSH

    Animals
    Arecaceae
    Brazil
    Deoxyribose
    Diazepam
    Free Radical Scavengers
    Fruit
    Hypnotics and Sedatives
    Male
    Medicine, Traditional
    Mice
    Motor Activity
    Nitric Oxide
    Plant Extracts
    Postural Balance
    Thiobarbituric Acid Reactive Substances

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22530310