Abstract

The antioxidant activities of aqueous extract (AE) of Orbignya phalerata were assessed in vitro as well as its effect on locomotor activity and motor coordination in mice. AE does not possesses a strong antioxidant potential according to the scavenging assays; it also did not present scavenger activity in vitro. Following oral administration, AE (1, 2 and 3 g/kg) did not significantly change the motor activity of animals when compared with the control group, up to 24 h after administration and did not alter the remaining time of the animals on the Rota-rod apparatus. Further studies currently in progress will enable us to understand the mechanisms of action of the aqueous extract of Orbignya phalerata widely used in Brazilian flok medicine.

Links

Publisher Full Text

Authors

Silva AP, Cerqueira GS, Nunes LC, de Freitas RM

Institution

Programa de Pós-graduação em Ciências Farmacêuticas, Núcleo de Tecnologia Farmacêutica, Laboratório de Pesquisa em Neuroquímica Experimental, Universidade Federal do Piauí (NTF/LAPNEX/UFPI), Teresina-Piauí, Brazil.

Source

Die Pharmazie 67:3 2012 Mar pg 260-3

MeSH

Animals
Arecaceae
Brazil
Deoxyribose
Diazepam
Free Radical Scavengers
Fruit
Hypnotics and Sedatives
Male
Medicine, Traditional
Mice
Motor Activity
Nitric Oxide
Plant Extracts
Postural Balance
Thiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22530310