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Comparison of topical triamcinolone and oral atorvastatin in treatment of paederus dermatitis Northern Iran.

Abstract

Dermatitis caused by stimulation of beetle paederus, is a common health problem in Northern and some southern parts of Iran. Since by now, traditional medicine and some corticosteroid agents have been used for treatment of dermatitis caused by beetle paederus. Because, there are few researches about classical treatment of the disease at academic level, this study planned to compare the effectiveness of triamcinolone ointment and atorvastatin tablet with placebo in treatment ofpaederus dermatitis in Northern Iran. A randomized double-blind clinical trial was carried out on 30 patients referred to the hospital and clinics at Sari and Neka countries in Northern Iran during 6 months. Patients were randomly divided into two therapeutic equal groups. The first group was triamcinolone ointment twice a day and a placebo atorvastatin tablet daily. The second group was oral atorvastatin one tablet (20 mg) daily and a placebo triamcinolone ointment twice a day. In Seventh day of visits, therapeutic response of the patients in triamcinolone and atorvastatin group were 93.33 and 80%, respectively. No significant differences were found in therapeutic outcome between the two groups (p > 0.05). The results showed both oftriamcinolone ointment and oral atorvastatin had similar effect on paederus dermatitis. Because the paederus dermatitis is a self-limited disease use of topical therapy for treatment of the disease is recommend.

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  • Authors

    Nikookar SH, Hajheydari Z, Moosa-Kazemi SH, Mahmoudi M, Shahmohammadi S

    Source

    Pakistan journal of biological sciences: PJBS 15:2 2012 Jan 15 pg 103-7

    MeSH

    Administration, Oral
    Administration, Topical
    Adolescent
    Adult
    Animals
    Beetles
    Child
    Dermatitis, Atopic
    Double-Blind Method
    Female
    Heptanoic Acids
    Humans
    Iran
    Middle Aged
    Placebos
    Pyrroles
    Treatment Outcome
    Triamcinolone
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22545364