Unbound MEDLINE

High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count.

Abstract

We describe an unintentional significant overdose of darunavir in a treatment-experienced adolescent with decreased darunavir susceptibility and prior treatment failure on darunavir therapy. Minimal toxicity and improved virologic suppression observed with an overdose have prompted consideration of the continued use of a higher than recommended dose. Pharmacokinetic and pharmacodynamic evaluations justified the individualized use of high-dose darunavir, which resulted in virologic suppression, improved CD4 cell count, and resolution of toxicity.

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  • Publisher Full Text

    • Authors

    Rakhmanina NY, Neely MN, Capparelli EV

    Institution

    Division of Infectious Diseases, Department of Pediatrics, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA. nrakhman@cnmc.org

    Source

    Therapeutic drug monitoring 34:3 2012 Jun pg 237-41

    MeSH

    CD4 Lymphocyte Count
    Child
    HIV Infections
    HIV Protease Inhibitors
    HIV-1
    Humans
    Male
    Prescription Drug Misuse
    Sulfonamides
    Treatment Outcome
    Viral Load

    Pub Type(s)

    Case Reports
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22549499