Abstract

A nodule was observed in the adrenal medulla of a twenty-week-old male Wistar Hannover rat. The nodule was predominantly (over 80%) composed of neural components, with ganglion cells scattered in sparse supporting tissue containing nerve fibers and Schwann cells. In the peripheral area of the tumor, atypical chromaffin cells were also observed. Accumulation of eosinophilic serous fluid was also noted in the stromal tissue. There were neither mitotic figures in the ganglion cells nor necrotic foci. In immunohistochemistry, the ganglion cells were positive for neuronal nuclei (NeuN), and negative for proliferating cell nuclear antigen, S-100, and chromogranin A. There were some NeuN-positive small cells in the peripheral area of the tumor. These findings indicate that this tumor was a ganglioneuroma. This seems to be an extremely rare case, as the spontaneous occurrence of ganglioneuroma in rats is very low, even in two-year carcinogenicity studies.

Links

Publisher Full Text

Authors

Shirai M, Kai K, Makino T, Maejima T, Kumagai K, Tanimoto T, Teranishi M, Sanbuissho A

Institution

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Fukuroi, Shizuoka, Japan. shirai.makoto.v7@daiichisankyo.co.jp

Source

Toxicologic pathology 40:5 2012 Jul pg 807-9

MeSH

Adrenal Medulla
Animals
Chromaffin Cells
Chromogranin A
Ganglioneuroma
Immunohistochemistry
Male
Neurons
Rats
Rats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22552389