Abstract

Arsenic exposure can result in damages of the neurological system. The present study aimed at whether cell proliferation and neurogenesis in the adult mouse hippocampus were affected after arsenic exposure and whether they could recover after exposure cessation. Mice were randomly placed into 3 groups. The first group received distilled water alone for 4 months (control group); the second group received 4.0 mg/L As(2)O(3) through drinking water for 4 months (arsenic group); the third group received 4.0 mg/L As(2)O(3) for 2 months and then changed to distilled water for another 2 months (recovery group). Serum and cerebrum arsenic concentrations of the arsenic group were significantly elevated, and then decreased to normal after the change of arsenic to water in the diet. After a four-month administration, the hippocampal number of proliferative cells and the percentage of new mature neurons decreased in the arsenic group as compared with the control group, however, increased significantly in the recovery group when compared with the arsenic group, and restored to the control level. There were no significant differences for apoptosis in different groups. Obvious histopathological ameliorations were observed in the hippocampus of the recovery group. The inhibition of hippocampus cell proliferation and neurogenesis by arsenic is reversible after the arsenic administration was terminated.

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Publisher Full Text

Authors

Liu S, Piao F, Sun X, Bai L, Peng Y, Zhong Y, Ma N, Sun W

Institution

Department of Occupational and Environmental Health, Dalian Medical University, Dalian 116044, PR China.

Source

Neurotoxicology 33:5 2012 Oct pg 1033-9

MeSH

Animals
Arsenic
Bromodeoxyuridine
Cell Death
Cell Proliferation
Gene Expression Regulation
Hippocampus
In Situ Nick-End Labeling
Male
Mice
Mice, Inbred Strains
Neural Inhibition
Neurogenesis
Phosphopyruvate Hydratase
Recovery of Function
Time Factors
Wnt3 Protein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22561869