Abstract

A cross-sectional study was made of the prevalence of HCV and associated risk factors in 382 multi-transfused patients and haemodialysis staff in Yadz province in 2006. Of those tested for anti-HCV antibodies, 50.6% of patients with inherited bleeding disorders, 11.8% with thalassaemia and 5.0% undergoing haemodialysis were seropositive. First transfusion before 1996 (when blood donor screening started) was the common risk factor associated with HCV infection. Only 1/52 haemodialysis staff members was HCV infected (an intravenous drug user). Infection control measures were poor in all centres. In patients with inherited bleeding disorders genotype 1 (65.0%) was the predominant followed by genotype 3 (35.0%). The results provide evidence that blood donor screening and use of virus-inactivated factor concentrates have lowered the risk of HCV infection among multi-transfused patients.

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Authors

Samimi-Rad K, Hosseini M, Mobeini G, Asgari F, Alavian SM, Tahaei ME, Salari H

Institution

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. ksamimirad@sina.tums.ac.ir

Source

Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ 18:3 2012 Mar pg 227-35

MeSH

Adolescent
Adult
Blood Transfusion
Child
Cross-Sectional Studies
Female
Hematologic Diseases
Hemodialysis Units, Hospital
Hepatitis C
Humans
Iran
Male
Occupational Diseases
Prevalence
Renal Dialysis
Risk Factors
Substance Abuse, Intravenous
Young Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22574475