Unbound MEDLINE

Iron deficiency in Yemeni patients with sickle-cell disease.

Abstract

Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency.

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  • Aggregator Full Text
  • Authors

    Kassim A, Thabet S, Al-Kabban M, Al-Nihari K

    Source

    Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ 18:3 2012 Mar pg 241-5

    MeSH

    Adolescent
    Adult
    Anemia, Iron-Deficiency
    Anemia, Sickle Cell
    Blood Transfusion
    Child
    Child, Preschool
    Comorbidity
    Female
    Humans
    Infant
    Male
    Reticulocyte Count
    Yemen
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22574477