Abstract

This study presents an application of the piecewise rational quadratic interpolant to the AUC calculation in the bioavailability study. The objective of this work is to find an area under the plasma concentration-time curve (AUC) for multiple doses of salbutamol sulfate sustained release tablets (Ventolin oral tablets SR 8 mg, GSK, Pakistan) in the group of 24 healthy adults by using computational mathematics techniques. Following the administration of 4 doses of Ventolin tablets 12 hourly to 24 healthy human subjects and bioanalysis of obtained plasma samples, plasma drug concentration-time profile was constructed. The approximated AUC was computed by using computational mathematics techniques such as extended rectangular, extended trapezium and extended Simpson's rule and compared with exact value of AUC calculated by using software - Kinetica to find best computational mathematics method that gives AUC values closest to exact. The exact values of AUC for four consecutive doses of Ventolin oral tablets were 150.58, 157.81, 164.41 and 162.78 ngxh/mL while the closest approximated AUC values were 149.24, 157.33, 164.25 and 162.28 ngxh/mL, respectively, as found by extended rectangular rule. The errors in the approximated values of AUC were negligible. It is concluded that all computational tools approximated values of AUC accurately but the extended rectangular rule gives slightly better approximated values of AUC as compared to extended trapezium and extended Simpson's rules.

Authors

Akhter KP, Ahmad M, Khan SA, Ramzan M, Shafi I, Muryam B, Javed Z, Murtaza G

Institution

Department of Mathematics, the Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

Source

Acta poloniae pharmaceutica 69:1 pg 81-5

MeSH

Administration, Oral
Adult
Albuterol
Area Under Curve
Biological Availability
Bronchodilator Agents
Cross-Over Studies
Delayed-Action Preparations
Humans
Male
Models, Biological
Models, Statistical
Pakistan
Software
Tablets

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

22574510