Abstract

The direct compression suitability of active pharmaceutical ingredients could be studied by SeDeM diagram method. Cefuroxime axetil (CfA) and paracetamol (PCM) were employed for SeDeM studies as these powders are well-characterized and known to be particularly difficult with respect to flowability and compactibility. Twelve different selected pharmacotechnical parameters were determined experimentally and were treated mathematically for being expressed in graphic representation as SeDeM diagram. Parameter index, parameter profile index and good compression index were calculated for both the selected drugs. Good compression index was found to be 2.19 and 1.36 for CfA and PCM, respectively, indicating poor direct compression characteristics of the selected drugs. The results from this SeDeM diagram method are in line with the previously reported studies where it was established as a reliable method for preformulation studies and as a quality control tool for studying batch-to-batch reproducibility of API's. Furthermore, it once again established the notion that blending poorly compressible drugs with suitable ingredients followed by SeDeM studies could be used as method for identifying best excipient and calculating maximum amount of excipient required for direct compression of API.

Authors

Singh I, Kumar P

Institution

Chitkara College of Pharmacy, Chandigarh-Patiala National Highway, Rajpura - 140401, Patiala, Punjab, India. inderbirsingh2906@gmail.com

Source

Acta poloniae pharmaceutica 69:1 pg 87-93

MeSH

Acetaminophen
Cefuroxime
Chemistry, Pharmaceutical
Computer Graphics
Drug Compounding
Excipients
Expert Systems
Particle Size
Porosity
Powders
Pressure
Rheology
Technology, Pharmaceutical
Wettability

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22574511