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Effect of photorefractive keratectomy with mitomycin-C on corneal biomechanical features.

Abstract

PURPOSE
To evaluate corneal biomechanical properties and intraocular pressure (IOP) after photorefractive keratectomy (PRK) with or without mitomycin-C (MMC) 0.02% in myopic eyes.
METHODS
In this prospective, comparative interventional case series, 33 right eyes of 33 patients were included. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP (IOPg), and cornea-compensated IOP (IOPcc) were measured using ocular response analyzer (ORA) before and 3 months after PRK. IOP was determined using Goldmann applanation tonometry (GAT). The pre- and post-operative values were compared. Effects of ablation depth, optical zone (OZ) and duration of MMC application on corneal biomechanics were examined.
RESULTS
Mean ablation depth was 56.6 ± 20.8 μm. Postoperatively, there was a significant reduction in corneal biomechanics and IOP readings by the GAT and ORA. Ablation depth was significantly associated with percentage change in CH (P = 0.021), CRF (P = 0.001), and IOP GAT (P < 0.001). However, the size of OZ and duration of MMC application did not have any correlation with these parameters. The percentage change in IOP GAT and IOPg but not IOPcc was significantly associated with percentage change in CH and CRF.
CONCLUSIONS
The corneal biomechanical strength significantly reduced after PRK which is associated to the amount of ablation. However, the OZ and the duration of MMC application did not affect these parameters. IOPcc appeared to be less dependent on altered corneal properties compared to IOPg and IOP GAT.

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  • Publisher Full Text

    • Authors

    Zare M, Feizi S, Azimzadeh A, Esfandiari H

    Institution

    Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    Source

    Current eye research 37:6 2012 Jun pg 457-62

    MeSH

    Adult
    Alkylating Agents
    Biomechanics
    Combined Modality Therapy
    Cornea
    Elasticity
    Female
    Humans
    Intraocular Pressure
    Lasers, Excimer
    Male
    Mitomycin
    Myopia
    Photorefractive Keratectomy
    Prospective Studies
    Tonometry, Ocular
    Visual Acuity
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    22577762