Abstract

Schizophrenia (SCZ) afflicts around 1% of the world's population with characteristic symptoms such as hallucinations, delusions, and cognitive disorders. Several experimental studies in the past have indicted brain histaminergic neuronal system involvement in the pathogenesis of psychotic disorders including SCZ. Present study investigates anti-schizophrenic activity using two histamine H(3)-receptor (H(3)R)-antagonists/inverse agonists, ciproxifan (3.0 mg/kg, i.p.) and clobenpropit (15 mg/kg, i.p.), on some of the established animal model of schizophrenia, for example, amphetamine (AMPH) and dizocilpine (MK-801)-induced hyperactivity, apomorphine (APO)-induced climbing behavior, scopolamine and MK-801-induced learning and memory deficits and haloperidol-induced catalepsy including determination of acetylcholinesterase (AChE) activity. Results of the present study demonstrate that ciproxifan and clobenpropitwere able to control AMPH and MK-801-induced hyperlocomotor activities demonstrated as reduced horizontal activity and reduced number of movements made by rats. Further, there was overall reduction in APO-induced climbing behavior. Learning and memory deficits, as evaluated on elevated plus maze, followed by estimation of brain AChE activity demonstrated positive results with these protypical imidazole H(3)R-antagonists/inverse agonists.

Links

Publisher Full Text

Authors

Mahmood D, Khanam R, Pillai KK, Akhtar M

Institution

Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India.

Source

Pharmacological reports : PR 64:1 2012 pg 191-204

MeSH

Acetylcholinesterase
Animals
Behavior, Animal
Brain
Catalepsy
Female
Histamine Antagonists
Imidazoles
Learning Disorders
Ligands
Male
Memory Disorders
Mice
Motor Activity
Rats
Rats, Wistar
Receptors, Histamine H3
Schizophrenia
Thiourea

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22580536