Abstract

AIM
It is aimed to share the fact that hemodialysis is also useful in carbamazepine intoxications with prominent neurological side effects in cases hemoperfusion is not available.
PATIENTS AND METHOD
Files of 49 patients presenting our Emergency Room with a prediagnosis of carbamazepine intoxication were analyzed retrospectively. Demographic and laboratory data of patients were recorded on study form. Patients were divided into two groups as those applied hemodialysis (Group 1) and those not applied hemodialysis (Group 2). Group 1 included 13 patients while group 2 did 36.
RESULTS
Statistically significant differences were detected between groups in terms of heart rate, Glasgow Coma scale score, presence of convulsions, midriasis and blood carbamazepine levels at the time of presentation. It was observed that carbamazepine levels decreased by 58% via hemodialysis in those receiving hemodialysis.
DISCUSSION
Hemodialysis is simple, cheap, widespread and easier to apply compared to hemoperfusion. It has been shown that acute carbamazepine intoxication can be treated with low flow-high activity standard hemodialysis and it is a good therapeutic option.

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Authors

Ozhasenekler A, Gökhan S, Güloğlu C, Orak M, Ustündağ M

Institution

Department of Emergency Medicine, School of Medicine, University of Dicle, Diyarbaktr, Turkey. drhasenek@mynet.com

Source

European review for medical and pharmacological sciences 16 Suppl 1: 2012 Mar pg 43-7

MeSH

Adult
Anticonvulsants
Antidotes
Carbamazepine
Charcoal
Female
Gastric Lavage
Glasgow Coma Scale
Heart Rate
Humans
Male
Neurotoxicity Syndromes
Overdose
Renal Dialysis
Retrospective Studies
Suicide, Attempted
Young Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22582484