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Differential gene expression by oxyphil and chief cells of human parathyroid glands.
CONTEXTParathyroid oxyphil cells, whose function is unknown, are thought to be derived from chief cells. Oxyphil cells increase in number in parathyroid glands of patients with chronic kidney disease (CKD) and are even more abundant in patients receiving treatment for hyperparathyroidism with calcitriol and/or the calcimimetic cinacalcet.
OBJECTIVEWe examined oxyphil and chief cells of parathyroid glands of CKD patients for differential expression of genes important to parathyroid function.
DESIGN/SETTING/PARTICIPANTSParathyroid tissue from CKD patients with refractory hyperparathyroidism was immunostained for gene expression studies.
MAIN OUTCOME MEASUREImmunostaining for PTH, PTHrP, calcium-sensing receptor, glial cells missing 2, vitamin D receptor, 25-hydroxyvitamin D-1α-hydroxylase, and cytochrome c was quantified and expression reported for oxyphil and chief cells.
RESULTSExpression of all proteins analyzed, except for the vitamin D receptor, was higher in oxyphil cells than in chief cells.
CONCLUSIONHuman parathyroid oxyphil cells express parathyroid-relevant genes found in the chief cells and have the potential to produce additional autocrine/paracrine factors, such as PTHrP and calcitriol. Additional studies are warranted to define the secretory properties of these cells and clarify their role in parathyroid pathophysiology.
The Journal of clinical endocrinology and metabolism 97:8 2012 Aug pg E1499-505
Gene Expression Profiling
Parathyroid Hormone-Related Protein
Pub Type(s)Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't