Unbound MEDLINE

Analysis of variola and vaccinia virus neutralization assays for smallpox vaccines.

Abstract

Possible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.

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  • Authors

    Hughes CM, Newman FK, Davidson WB, Olson VA, Smith SK, Holman RC, Yan L, Frey SE, Belshe RB, Karem KL, Damon IK

    Institution

    National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Christine.Hughes@cdc.hhs.gov

    Source

    Clinical and vaccine immunology : CVI 19:7 2012 Jul pg 1116-8

    MeSH

    Antibodies, Neutralizing
    Antibodies, Viral
    Humans
    Neutralization Tests
    Smallpox Vaccine
    Vaccinia virus
    Variola virus

    Pub Type(s)

    Comparative Study
    Evaluation Studies
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22593237