Abstract

BACKGROUND
Extramedullary (EM) organ impairment in patients with multiple myeloma (MM) is a rare event, occurring mostly during disease relapse after high-dose chemotherapy with autologous or allogeneic stem cell transplantation. This manifestation is commonly associated with an unfavourable outcome. Previous studies suggested a correlation between the clinical course of patients with MM and EM and the cytogenetic findings, e.g. deletion of TP53 on 17p13.
MATERIALS AND METHODS
We investigated patients with these rare plasma cell organ infiltrations (n=17) as well as bone lesions or soft tissue lesions, known to be a common clinical feature of MM (n=14), using a newly established method of fluorescence in situ hybridization in combination with cytoplasmic immunoglobulin staining (cIg-FISH) on paraffin-embedded sections and a specific probe for TP53 on 17p13.
RESULTS AND CONCLUSION
The incidence of del(17)(p13) was similar in both groups but overall it was higher when compared to published data obtained from bone marrow samples and material originating from osteolyses. Further investigations on a larger patient cohort are needed in order to confirm these findings.

Links

Publisher Full Text

Authors

Billecke L, Penas EM, May AM, Engelhardt M, Nagler A, Leiba M, Schiby G, Kröger N, Zustin J, Marx A, Matschke J, Tiemann M, Goekkurt E, Bokemeyer C, Schilling G

Institution

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Germany.

Source

Anticancer research 32:5 2012 May pg 2031-4

MeSH

Aged
Aged, 80 and over
Chromosome Deletion
Chromosomes, Human, Pair 17
Female
Genes, p53
Humans
Male
Middle Aged
Multiple Myeloma
Osteolysis
Soft Tissue Neoplasms

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22593484