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A novel approach to the analysis of human growth.

Abstract

OBJECTIVES
Several formulations have been proposed in order to model human growth from birth to maturity. They are usually based on "ad hoc" heuristic assumptions. In the present contribution we adopt, as an alternative, a completely general (interdisciplinary) approach, based on the formalism of the Phenomenological Universalities (PUN).
METHODS
The main PUN class investigated to date, i.e. UN, can only account for the overall growth pattern. For a realistic description it is necessary to add to it one or more "spurts", as expected on biological grounds, due to the stimulation of growth and sex hormones.
RESULTS
A new PUN class (UN + FM) is generated and shown to be able to provide excellent agreement with standard auxological datasets. The accuracy of the fitting and reliability of the model suggest applications both at the diagnostic and therapeutic level.
CONCLUSIONS
The developed formalism can be suitably related to the biological description of bone plate growth under selective hormonal stimulation on the bone epiphysis; i.e., the additional increase of stature is the "macroscopic" response to a well defined biological signal.

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  • Authors

    Gliozzi AS, Guiot C, Delsanto PP, Iordache DA

    Source

    Theoretical biology & medical modelling 9: 2012 pg 17

    MeSH

    Adolescent
    Aging
    Body Height
    Child
    Child, Preschool
    Female
    Great Britain
    Growth and Development
    Humans
    Infant
    Male
    Models, Biological
    Noonan Syndrome
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22594680