Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry.
Biomarkers have the potential to improve the clinical management of patients with AAA.
A prospective, proteomics discovery study was undertaken to compare patients with AAA (n = 20) to matched screened controls (n = 19) for plasma protein expression. Surface-Enhanced-Laser-Desorption-Ionization Time of Flight Mass Spectrometry (SELDI ToF MS) coupled with Artificial Neural Networks (ANN) analysis identified six protein related diagnostic biomarker ions with a combined AUC of 0.89.
This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible.
Department of Cardiovascular Sciences, University of Leicester, UK. firstname.lastname@example.org
SourceEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 44:1 2012 Jul pg 52-4
Aged, 80 and over
Aortic Aneurysm, Abdominal
Reproducibility of Results
Severity of Illness Index
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Pub Type(s)Comparative Study