Abstract

INTRODUCTION
Biomarkers have the potential to improve the clinical management of patients with AAA.
REPORT
A prospective, proteomics discovery study was undertaken to compare patients with AAA (n = 20) to matched screened controls (n = 19) for plasma protein expression. Surface-Enhanced-Laser-Desorption-Ionization Time of Flight Mass Spectrometry (SELDI ToF MS) coupled with Artificial Neural Networks (ANN) analysis identified six protein related diagnostic biomarker ions with a combined AUC of 0.89.
DISCUSSION
This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible.

Links

Publisher Full Text

Authors

Ehsan S, Ball G, Choke E, Molyneux KM, London NJ, Herbert KE, Barratt J, Sayers RD, Bown MJ

Institution

Department of Cardiovascular Sciences, University of Leicester, UK. se63@le.ac.uk

Source

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 44:1 2012 Jul pg 52-4

MeSH

Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal
Biological Markers
Disease Progression
Humans
Male
Prospective Studies
Proteomics
Reproducibility of Results
Severity of Illness Index
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22595147