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Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.

Abstract

BACKGROUND
Essential tremor is the most common movement disorder in adults, but its exact etiology and pathophysiology are still not fully understood. There is some consensus, however, about the involvement of the cerebellum and accumulating evidence points towards a dysfunction of the gabaergic system. We hypothesize that the serotonin neurotransmission system may also play a role as it does in tremor in Parkinson disease. This study aimed to investigate the association between the severity of tremor symptoms and the gabaergic and serotoninergic neurotransmission systems in essential tremor.
MATERIAL AND METHODS
We measured the tremor clinical rating scale score and acquired DASB and Flumazenil PET scans in 10 patients who presented with essential tremor at different stages of clinical severity. Statistically significant correlations were sought between the scale scores and parametric binding potential images.
RESULTS
The correlation analysis of cerebellar Flumazenil uptake and tremor clinical rating scale scores reached statistical significance (R2 = 0.423, p = 0.041), whereas no association was detected in the DASB scans.
CONCLUSIONS
The severity of tremor correlated with the abnormalities found in GABA receptor binding, suggesting a primary gabaergic deficiency or a functional abnormality at the level of GABA(A) receptor subtypes. These results may assist in the rational development of new pharmacological treatments for essential tremor.

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  • Publisher Full Text
  • Authors

    Gironell A, Figueiras FP, Pagonabarraga J, Herance JR, Pascual-Sedano B, Trampal C, Gispert JD

    Source

    Parkinsonism & related disorders 18:7 2012 Aug pg 876-80

    MeSH

    Aged
    Cerebellum
    Essential Tremor
    Female
    Flumazenil
    Humans
    Image Processing, Computer-Assisted
    Male
    Middle Aged
    Neuroimaging
    Parkinson Disease
    Positron-Emission Tomography
    Serotonin
    gamma-Aminobutyric Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22595620