Abstract

Biomolecular systems that can process information are sought for computational applications, because of their potential for parallelism and miniaturization and because their biocompatibility also makes them suitable for future biomedical applications. DNA has been used to design machines, motors, finite automata, logic gates, reaction networks and logic programs, amongst many other structures and dynamic behaviours. Here we design and program a synthetic DNA network to implement computational paradigms abstracted from cellular regulatory networks. These show information processing properties that are desirable in artificial, engineered molecular systems, including robustness of the output in relation to different sources of variation. We show the results of numerical simulations of the dynamic behaviour of the network and preliminary experimental analysis of its main components.

Links

PMC Free PDF

PMC Free Full Text

Authors

Santini CC, Bath J, Turberfield AJ, Tyrrell AM

Institution

Department of Electronics, University of York, York YO10 5DD, UK; E-Mail: ccsantini@gmail.com.

Source

International journal of molecular sciences 13:4 2012 pg 5125-37

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22606034