Wnt-4 potently inhibits capillary outgrowth from rat aorta in 3D culture.
Regulation of angiogenesis involves tight cell-to-cell and cell-to-extracellular-matrix interactions. Various reports demonstrate that the Wnt signaling pathways participate in this regulation. Using a three-dimensional aortic ring culture combined with an ex vivo retroviral infection approach, we evaluated the effects of two Wnt growth factors, Wnt-1 and Wnt-4, on the formation and growth of new capillaries. Our results show that Wnt-1 had no effect, whereas Wnt-4 was a potent inhibitor of capillary outgrowth in vitro.
Groupe Rein & Hypertension, Institut Universitaire de Recherche Clinique, CNRS FRE3400, 641 Ave Doyen Giraud, 34093, Montpellier Cedex 5, France.
SourceFundamental & clinical pharmacology : 2012 May 2 pg
Pub Type(s)JOURNAL ARTICLE