Abstract

OBJECTIVE
We conducted a study to evaluate the correlation between pre-operative endometrial sampling to the final endometrial cancer histology, in particular the non-endometrioid subtypes.
METHODS
This involved 191 hysterectomy specimens of patients undergoing treatment at the Pan-Birmingham Gynaecological Regional Cancer Centre (BGCC) over a two-year period (2006-2007).
RESULTS
The majority of the patients in this study were found to have endometrioid histology subtype (140/191, 73%). However, the non-endometrioid histologic subtypes were well presented in our population (51/191, 27%). We found good correlation for endometriod histology subtype (78%) and certain types of the non-endometrioid cell types (carcinosarcoma 90%, uterine papillary serous carcinoma 67%, clear cell carcinoma 67%) but poor in sarcomas (40%). Our results also demonstrated that both pre-operative endometrial sampling methods (curettage and pipelle biopsy) were reliable in identifying endometrioid and non-endometrioid cancer cell types, with sensitivities of 96.5% and 86.5%, respectively.
CONCLUSION
We concluded that preoperative endometrial sampling had good overall histological correlation to hysterectomised corpus specimen. This is especially so for the endometrioid and certain subtypes of the non-endometrioid endometrial cancer cells.

Authors

Sany O, Singh K, Jha S

Institution

Pan-Birmingham Gynaecology Cancer Centre, Sandwell and West Birmingham NHS Trust, UK. omarsany@hotmail.com

Source

European journal of gynaecological oncology 33:2 2012 pg 142-4

MeSH

Adenocarcinoma, Clear Cell
Biopsy
Carcinoma, Endometrioid
Carcinoma, Papillary
Carcinosarcoma
Dilatation and Curettage
Endometrial Neoplasms
Endometrium
Female
Humans
Predictive Value of Tests
Sarcoma

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22611951