Abstract

INTRODUCTION
This study documents 25(OH)D status and bone mineral density (BMD) in women of reproductive (WR) and post-menopausal (PMW) age-groups in south India.
SUBJECTS AND METHODS
Serum calcium (Ca), phosphorus (iP), albumin, alkaline phosphatase (ALP), creatinine, 25(OH)D and intact parathormone (N-tact PTH) of WR (n = 55) and PMW (n = 136) women were analyzed over a period of one year. Bone mineral Density (BMD) (Hologic, USA) was estimated using Caucasian data as reference.
RESULTS
In both, WR and in PMW 25(OH)D deficiency (< 20 ng/ml), insufficiency (20-30 ng/ml) and replete states (> 30 ng/ml) were seen in 76%, 16.5%, 7.5% vs 70%, 23% and 7% respectively. PMW had lower BMD (gm/cm2) than WR at forearm ( P = < 0.001), hip trochanter (P = < 0.0001), lumbar spine antero-posterior (LSAP) (P = < 0.001) and lateral (LS Lateral) (P = < 0.001). Osteoporosis was seen at hip (15% and 28%), forearm (nil and 11%), LSAP (6% and 22%) and LS lateral (0% and 23%) among WR and PMW respectively. BMD did not correlate with any of the biochemical indices but correlated with BMD at other sites.
CONCLUSIONS
Vitamin D deficiency coexists with low BMD in our study group. Serum 25(OH)D needs to be documented in women having low BMD. Calcium and vitamin D need to be supplemented as part of therapy in PMW.

Authors

Harinarayan CV, Sachan A, Reddy PA, Satish KM, Prasad UV, Srivani P

Institution

Department of Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati--517 507, Andhra Pradesh, India.

Source

The Journal of the Association of Physicians of India 59: 2011 Nov pg 698-704

MeSH

Absorptiometry, Photon
Adult
Aged
Arm
Biological Markers
Bone Density
Calcium
Cross-Sectional Studies
Female
Femur
Humans
India
Lumbar Vertebrae
Middle Aged
Parathyroid Hormone
Postmenopause
Prevalence
Vitamin D
Vitamin D Deficiency
Young Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22616335