Abstract

OBJECTIVE
To compare the efficacy of neoadjuvant paclitaxel-carboplatin chemotherapy followed by radical hysterectomy with radical hysterectomy alone in patients with bulky cervical cancer stage IB2-IIA.
MATERIAL AND METHOD
From January 2000 through December 2009, 80 patients with bulky cervical cancer stage IB2-IIA that received neoadjuvant paclitaxel-carboplatin chemotherapy (n = 40) or immediate primary surgery (n = 40) were reviewed. The efficacy of neoadjuvant chemotherapy on the basis of feasibility in operation and pathological prognostic factors and the percentage of patients who needed postoperative adjuvant concurrent chemoradiation therapy were compared.
RESULTS
There were no significant differences between group in age, tumor size, FIGO staging, histologic type and grading at the time of diagnosis. All patients in neoadjuvant chemotherapy group successfully underwent radical hysterectomy. The pathological findings included tumor size, deep cervical invasion, parametrial involvement, positive surgical margin and lymphovascular space invasion were statistically significant decrease in neoadjuvant chemotherapy group. Nevertheless, the pelvic nodal metastasis was not different between both groups. Adjuvant concurrent chemoradiation therapy had a statistically significant decrease in the neoadjuvant chemotherapy group.
CONCLUSION
Neoadjuvant chemotherapy significant by improves the feasibility in operation and the pathological prognostic factors, and decreases the percentage of patients who needed postoperative adjuvant concurrent chemoradiation therapy.

Authors

Prueksaritanond N, Chaisarn P, Yanaranop M

Institution

Department of Obstetrics and Gynecology Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. nisa3054@gmail.com

Source

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 95 Suppl 3: 2012 Mar pg S55-61

MeSH

Adult
Antineoplastic Agents, Phytogenic
Antineoplastic Combined Chemotherapy Protocols
Carboplatin
Chemotherapy, Adjuvant
Female
Humans
Hysterectomy
Middle Aged
Neoadjuvant Therapy
Neoplasm Invasiveness
Neoplasm Staging
Paclitaxel
Retrospective Studies
Uterine Cervical Neoplasms

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22619888