Abstract

Haematopoietic cell transplantation (HCT) is the most widely used form of cellular therapy. It is the only known cure for some haematological malignancies and has recently been used in additional clinical settings, such as allograft tolerance induction and treatment of autoimmune diseases. Recent advances have enabled HCT in a wider range of patients with improved outcomes. This Review summarizes the latest developments in this therapy, focusing on issues that will affect future advancement.

Links

Publisher Full Text

Authors

Li HW, Sykes M

Institution

Columbia Center for Translational Immunology, Columbia University Medical Center, 650 West 168th Street, BB 15-02, New York, New York 10032, USA.

Source

Nature reviews. Immunology 12:6 2012 Jun pg 403-16

MeSH

Animals
Autoimmune Diseases
Fetal Blood
Graft vs Host Disease
HLA Antigens
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Humans
Transplantation Conditioning

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22627859