Abstract

Cancer-related cachexia, a condition in which the body is consumed by deranged carbohydrate, lipid and protein metabolism that is induced by inflammatory cytokines. Cachexia is associated with poor treatment outcome, fatigue and poor quality of life. Pharmacological intervention in the treatment and/or prevention of cachexia has been mainly aimed at the use of appetite enhancers to increase oral nutritional intake so far. Herbal remedies are part of traditional and folk healing methods with long histories of use. In this report, we have assessed which herbal approaches have had associated cancer cachexia case reports. Commonly used herbal medicines in western countries include essiac, iscador, pau d'arco tea, cannabinoids and so on. Some Kampo herbs and formulations are commonly used by cancer patients reduce the side effects and complications during the antitumor therapy. The relevant herbal medicines include ginseng, C. rhizome and radix astragali, and the related herbal remedies, such as TJ-48, TJ-41, PHY906 and Rikkunshito. However, there still have some adverse effects caused or amplified by herb and drug interactions that are difficult to separate. However, randomized effectiveness of herbal medicines shall be further identified in controlled clinical trials involving cancer patients with cachexia.

Links

Publisher Full Text

Authors

Cheng KC, Li YX, Cheng JT

Institution

Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City 890-8520, Japan. sa_tatonma@yahoo.com.tw

Source

Current pharmaceutical design 18:31 2012 pg 4819-26

MeSH

Animals
Anorexia
Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents
Antioxidants
Appetite Stimulants
Cachexia
Dietary Supplements
Gastrointestinal Agents
Humans
Medicine, Traditional
Neoplasms
Plant Preparations
World Health

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22632862