Abstract

Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7(+) naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4(+) T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. Notably, lymphotoxin-expressing B cells, CXCR5-expressing DCs and T cells, and CXCL13 were also necessary for development of interleukin 4 (IL-4)-producing type 2 helper T cells (T(H)2 cells), which suggests that T(H)2 differentiation can initiate outside the T cell zone.

Links

Publisher Full Text

Authors

León B, Ballesteros-Tato A, Browning JL, Dunn R, Randall TD, Lund FE

Institution

Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA.

Source

Nature immunology 13:7 2012 Jul pg 681-90

MeSH

Animals
B-Lymphocytes
Chemokine CXCL13
Dendritic Cells
Interleukin-4
Lymphocyte Activation
Lymphotoxin-alpha
Mice
Mice, Inbred C57BL
Nematospiroides dubius
Receptors, CXCR5
Strongylida Infections
Th2 Cells

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22634865