Abstract

Varicella zoster virus reactivation often occurs in the setting of impaired immunity, which is generally present in patients with end-stage renal disease (ESRD). Therapy for variceIla zoster virus infection is well established. However, it is often been forgotten that acyclovir dosage should be adjusted to renal function. We point to the problem encountered in clinical practice when ESRD patient presents with cutaneous herpes zoster and neurological symptoms. Clinical findings alone may prove inadequate to determine whether neurological deficit is caused by infection of the central nervous system or is a consequence of acyclovir induced neurotoxicity.

Authors

Mesar I, Basić-Jukić N, Hudolin T, Katalinić L, Kes P

Institution

University Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb University Hospital Center, Zagreb, Croatia. inesmesar@yahoo.com

Source

Acta clinica Croatica 50:4 2011 Dec pg 549-52

MeSH

Acyclovir
Aged
Antiviral Agents
Female
Herpes Zoster
Herpesvirus 3, Human
Humans
Immunocompromised Host
Kidney Failure, Chronic
Male
Middle Aged
Renal Dialysis
Virus Activation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22649885