Abstract

Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and populations. These diseases result from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This paper reviews the abnormal bone metabolism associated with CD, in order to elucidate the mechanism of bone loss.

Links

Publisher Full Text

Authors

Wu T, Song HY, Ji G

Institution

Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Source

Frontiers in bioscience : a journal and virtual library 17: 2012 pg 2675-83

MeSH

Adrenal Cortex Hormones
Antibodies, Monoclonal
Bone Diseases, Metabolic
Bone Remodeling
Bone and Bones
Calcium
Crohn Disease
Female
Humans
Male
Models, Biological
Risk Factors
Tumor Necrosis Factor-alpha
Vitamin D
Vitamin D Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22652805