Abstract

Pancytopenia is not a disease but an important clinico-haematological entity encountered in our day-to-day clinical practice with findings that may result from a number of disease processes. A total of 100 patients of pancytopenia admitted in medicine wards of Civil Hospital, Ahmedabad, Gujuarat, India, were studied. The most common cause of pancytopenia was megaloblastic anaemia (45%) followed by infections (20%) and hypersplenism (15%). As compared with other causes, megaloblastic anaemia was statistically significant cause (P < 0.01) of pancytopenia, in our study. The most common clinical presentation of patients with megaloblastic anaemia was lethargy (100%) and pallor (100%). In patients with megaloblastic anaemia, mean haemoglobin (Hb) was 5.6 ± 1.7 g/dl, mean white blood corpuscle (WBC) count was 2735 ± 4152 and mean platelet count was 52,250 ± 24,213. Mean corpuscular volume (MCV) was 101.2 ± 11 in patients of megaloblastic anaemia. Morphology of RBC was marocytic in 95% of patients with megaloblastic anaemia, whereas hypersegmented neutrophils and macrovalocytes were seen in 60-65% patients of megaloblastic anaemia.

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Publisher Full Text

Authors

Doshi D, Shah AN, Somani S, Jain A, Jivarajani H, Kothari P

Institution

Medicine Department, D-4 Civil Hospital, Ahmedabad, Gujarat, India.

Source

Hematology (Amsterdam, Netherlands) 17:2 2012 Mar pg 100-5

MeSH

Adult
Aged
Anemia, Megaloblastic
Blood Cell Count
Communicable Diseases
Community Health Centers
Erythrocyte Indices
Humans
Hypersplenism
India
Lethargy
Middle Aged
Pallor
Pancytopenia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22664048