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Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration.

Abstract

The use of global gene expression profiling, also known as transcriptomics or genomics, provides a means to identify key pathways affected in ageing skin that can be improved with appropriate cosmetic compounds. Aspects of skin ageing that can be addressed include matrix production, barrier, lipid synthesis, antioxidant capacity and hyperpigmentation. Gene expression profiling together with in vitro human skin cell cultures for compound screening and verification have led to the identification of cosmetic compounds and an understanding of the biological effects of compounds such as niacinamide, Pal-KTTKS, hexamidine, retinyl propionate and sodium dehydroacetate. In addition, understanding of the decreased antioxidant capacity of aged skin has led to the identification of new antiageing ingredients, olive-derived fatty acid ethoxylates, which have been shown to restore antioxidant enzymes in skin keratinocytes and fibroblasts. Gene expression profiling of age spots has also provided an understanding of the role of undecylenoyl phenylalanine in reducing melanin production by an adrenergic receptor mechanism in melanocytes. The use of these compounds in cosmetic formulations for skin care can aid improvements in the appearance of aged skin, including the improved appearance of fine lines, wrinkles and age spots.

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  • Publisher Full Text
  • Authors

    Osborne R, Hakozaki T, Laughlin T, Finlay DR

    Source

    The British journal of dermatology 166 Suppl 2: 2012 Jun pg 16-9

    MeSH

    Antioxidants
    Cosmetics
    Fatty Acids
    Genomics
    Humans
    Pigmentation Disorders
    Plant Oils
    Receptors, Adrenergic, beta
    Skin Aging
    Skin Pigmentation
    Transcription, Genetic
    Up-Regulation

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22670614