Abstract

PURPOSE
To determine if there is an increased frequency of abnormal hypoosmotic swelling (HOS) tests when testing semen in males of advanced reproductive age.
METHODS
Ten-year retrospective review according to six age groups (< or = 29.9, 30-34.9, 35-39.9, 40-44.9, 45.0-49.9, and > or = 50).
RESULTS
Compared to males < 35 years old, the frequency of HOS scores < 50% doubles in males 45-49.9 and quadruples in males > or = 50.
CONCLUSIONS
Males with low HOS scores despite having no problem with fertilization of the oocytes rarely achieve a pregnancy because of embryo implantation defects unless intracytoplasmic sperm injection (ICSI) is performed. Thus at least one abnormality seen in sperm of males of advanced reproductive age is correctable by performing in vitro fertilization with ICSI.

Authors

Check JH, Kramer D, Bollendorf A, Wilson C

Institution

The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com

Source

Clinical and experimental obstetrics & gynecology 39:1 2012 pg 19-20

MeSH

Adult
Aging
Embryo Implantation
Humans
Infertility, Male
Male
Middle Aged
Osmolar Concentration
Retrospective Studies
Semen Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22675947