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RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 6: Post-cardiac arrest care.

Abstract

OBJECTIVE
To systematically examine the evidence for interventions after the return of spontaneous circulation (ROSC) on outcomes from veterinary cardiopulmonary resuscitation and to determine important knowledge gaps.
DESIGN
Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical post-cardiac arrest care.
SETTING
Academia, referral practice, and general practice.
RESULTS
Fifteen standardized clinical questions important for post-cardiac arrest care were asked and research articles relevant to answering these questions were identified through structured, explicit literature database searches. The majority of these articles report research in species other than dogs or cats or consisted of experimental work in canine cardiac arrest models. Outcome metrics reported in these studies widely varied and ranged from quantification of mechanistic endpoints, such as elaboration of reactive oxygen species, to survival, and functional neurologic outcome.
CONCLUSIONS
Despite the near complete absence of clinical veterinary studies, the process allowed the formulation of statements for several postcardiac arrest treatments that were either supportive, such as mild therapeutic hypothermia or controlled reoxygenation, or neutral, such as for mannitol administration or seizure prophylaxis. Evidence grading allowed transparency in regards to the strength of these recommendations. Moreover, numerous knowledge gaps emerged that will allow generation of a road map for progress in veterinary post-cardiac arrest care.

Links

  • Publisher Full Text

    • Authors

    Smarick SD, Haskins SC, Boller M, Fletcher DJ, RECOVER Post-Cardiac Arrest Care Domain Worksheet Authors

    Institution

    AVETS, Monroeville, PA 15146, USA. smarick@avets.us

    Source

    Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 22 Suppl 1: 2012 Jun pg S85-101

    MeSH

    Aftercare
    Animals
    Cardiopulmonary Resuscitation
    Cats
    Dogs
    Evidence-Based Medicine
    Health Knowledge, Attitudes, Practice
    Heart Arrest
    Humans
    Practice Guidelines as Topic
    Survival Rate
    Treatment Outcome
    Veterinarians
    Veterinary Medicine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22676288