Abstract

Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis.

Links

Publisher Full Text

Authors

Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B

Institution

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai 200025, People's Republic of China.

Source

FEBS letters 586:16 2012 Jul 30 pg 2382-8

MeSH

3' Untranslated Regions
Aged
Animals
Cell Line, Tumor
Cell Movement
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Lymphatic Metastasis
Male
Mice
Mice, Nude
MicroRNAs
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Protein-Serine-Threonine Kinases
Stomach Neoplasms
Transfection
Wound Healing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22677169