Abstract

We determined the pharmacokinetics of efavirenz in plasma and cerebrospinal fluid (CSF) over a 24-h dosing interval in a patient who had undergone a lumbar drain because of cryptococcal meningitis. Drug concentrations were determined by high-performance liquid chromatography-tandem mass spectrometry in paired CSF (n = 24) and plasma (n = 25) samples. The median plasma efavirenz concentration was 3,718 ng/ml (range, 2,439 to 4,952), and the median CSF concentration was 16.3 ng/ml (range, 7.3 to 22.3). The CSF/plasma area-under-the-curve ratio was 0.0044 corresponding to a CSF penetration of 0.44% of plasma.

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Authors

Yilmaz A, Watson V, Dickinson L, Back D

Institution

Department of Infectious Diseases, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. aylin.yilmaz@gu.se

Source

Antimicrobial agents and chemotherapy 56:9 2012 Sep pg 4583-5

MeSH

Anti-HIV Agents
Antifungal Agents
Area Under Curve
Benzoxazines
Chromatography, High Pressure Liquid
Coinfection
Cryptococcus neoformans
HIV
HIV Infections
Half-Life
Humans
Male
Meningitis, Cryptococcal
Middle Aged
Tandem Mass Spectrometry

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22687515