Abstract

CONCLUSION
This is the first report demonstrating high levels of substance P (SP) that inversely correlate with vasoactive intestinal peptide (VIP) levels in middle ear effusions (MEEs) of patients with otitis media with effusion (OME). Increased SP and decreased VIP levels might play a role in the pathogenesis of chronic OME.
OBJECTIVE
The etiology of OME is multifactorial, and neurogenic inflammation may play a significant role. SP and VIP levels were not evaluated previously in MEEs of children with OME.
METHODS
Fifty patients aged 2-12 years (mean age 5.24 ± 2.64) were included in the study. MEEs were classified as mucoid or serous based on the gross appearance. SP and VIP levels were determined using ELISA.
RESULTS
High levels of SP were detected in MEEs. In addition SP levels were significantly higher in serous samples (2910.55 ± 307.96 vs 2218.55 ± 262.30 pg/ml). There were also age-dependent changes, such that SP levels were significantly higher in children aged 2-3 years compared with those who were 4-5 and 6-12 years old. VIP levels were undetectable in 30% of patients and the mean level of VIP was 50.91 ± 16.01 pg/ml in serous middle ear effusions and 54.86 ± 15.91 pg/ml in mucoid MEEs.

Links

Publisher Full Text

Authors

Eyigor H, Osma U, Yilmaz MD, Eyigor M, Gultekin M, Erin N

Institution

Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital, Turkey. hulinar@yahoo.com

Source

Acta oto-laryngologica 132:10 2012 Oct pg 1036-41

MeSH

Age Factors
Biological Markers
Child
Child, Preschool
Chronic Disease
Cohort Studies
Disease Progression
Female
Humans
Male
Otitis Media with Effusion
Prognosis
Prospective Studies
Recurrence
Sensitivity and Specificity
Severity of Illness Index
Sex Factors
Statistics, Nonparametric
Substance P
Vasoactive Intestinal Peptide

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22691066