Abstract

A 58-year-old woman was admitted with left-sided decreased sensation, ataxia, and left "alien" hand and leg. Brain SPECT and PET showed hypoperfusion and hypometabolism in the right frontoparietal cortices, including the primary sensorimotor cortex, and temporal cortex. MRI demonstrated matching-restricted diffusion and fluid-attenuated inversion recovery hyperintensity. Corticobasal degeneration was suspected initially. The patient declined rapidly, and the diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) was made based on cerebrospinal fluid biomarkers. CJD can present with symptoms similar to other disorders. This case illustrates that CJD can mimic a rare neurodegenerative disorder, cortico-basal degeneration, both clinically and by neuroimaging.

Links

Publisher Full Text

Authors

Zhang Y, Minoshima S, Vesselle H, Lewis DH

Institution

Department of Radiology, University of Washington, Seattle, WA 98195-7115, USA.

Source

Clinical nuclear medicine 37:7 2012 Jul pg e173-5

MeSH

Cerebral Cortex
Creutzfeldt-Jakob Syndrome
Diagnosis, Differential
Female
Fluorodeoxyglucose F18
Humans
Magnetic Resonance Imaging
Middle Aged
Neurodegenerative Diseases
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22691528