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Acid phosphatase locus 1 genetic polymorphism and cancer grading.

Abstract

BACKGROUND
Currently, there is a surge of interest on the possible relationship between cancer and acid phosphatase locus 1 (ACP(1)), an enzyme involved in the modulation of growth factors and cellular metabolism. As far as the authors know, the possible relationship between ACP(1) genetic variability and cancer grading has not yet been considered. In this article, the authors have studied the relationship between ACP(1) genotype and grade in colon and endometrium cancers.
METHODS
Seventy-one patients with colon cancer and 71 patients with endometrium cancer were studied. ACP(1) genotype was determined by DNA analysis. Three-way contingency table analysis was carried out according to Sokal and Rohlf. Other statistical analyses were performed using SPSS programs.
RESULTS
There is a significant association between ACP(1) and cancer grade mainly due to ACP(1) genotypes carrying the *C allele that are much less represented in patients with low grade when compared with those with high grade. In both cancers, the concentration of S isoform is significantly lower in low grade than in high grade. The relationship between ACP(1) and grade is the same in the 2 cancers.
CONCLUSIONS
Assuming the presence of diverse classes of cancer, the role of ACP(1) in the modulation of growth factors and cellular metabolism could have significant effects in less aggressive forms but not in more aggressive ones.

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  • Publisher Full Text

    • Authors

    Gloria-Bottini F, Spina C, Nicotra M, Saccucci P, Ambrosi S, Bottini E

    Institution

    Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy. gloria@med.uniroma2.it

    Source

    The American journal of the medical sciences 344:1 2012 Jul pg 32-4

    MeSH

    Aged
    Colonic Neoplasms
    Endometrial Neoplasms
    Female
    Genetic Predisposition to Disease
    Humans
    Male
    Middle Aged
    Neoplasm Grading
    Odds Ratio
    Polymorphism, Genetic
    Protein Isoforms
    Protein Tyrosine Phosphatases
    Proto-Oncogene Proteins
    Rome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22692348