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The effects of montelukast against amikacin-induced acute renal damage.

Abstract

BACKGROUND AND OBJECTIVES
The therapeutic and protective effects of montelukast against amikacin-induced acute renal damage were investigated.
MATERIAL AND METHODS
35 Wistar albino female rats were divided into 5 groups as follows: Group I: Control; Group II: Control+montelukast; Group III: Amikacin; Group IV: Amikacin+montelukast; Group V: Montelukast+amikacin. At the end of the experiment, the kidney tissues and the blood of rats were collected. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined from kidney tissues. Blood urea nitrogen (BUN), creatinine (Cr), TNF-alpha, and IL-1beta levels were assessed in the serum. In addition the kidney tissues were examined histologically.
RESULTS AND DISCUSSION
The MDA, MPO, BUN, and Cr levels of group III significantly increased when compared to groups I and II. These parameters of group IV decreased when compared to group III. In addition, GSH levels significantly increased when compared to the first three groups. MDA, BUN and Cr levels of group V did not reach significant level in comparison with the control group. The most significant histological damage was observed in the group III followed by the groups IV and V. Immunohistochemically, group III showed a significantly increased apoptotic staining. In group IV, it was observed that montelukast treatment reduced the expression of apoptotic cells.
CONCLUSIONS
Montelukast treatment after amikacin injection could reduce the amikacin-induced kidney damage.

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  • Authors

    Kose E, Beytur A, Dogan Z, Ekincioglu Z, Vardi N, Cinar K, Turkoz Y, Soysal H, Ekinci N

    Source

    European review for medical and pharmacological sciences 16:4 2012 Apr pg 503-11

    MeSH

    Acetates
    Acute Disease
    Amikacin
    Animals
    Anti-Inflammatory Agents
    Antioxidants
    Apoptosis
    Blood Urea Nitrogen
    Creatinine
    Cytoprotection
    Disease Models, Animal
    Female
    Glutathione
    Immunohistochemistry
    Interleukin-1beta
    Kidney
    Kidney Diseases
    Malondialdehyde
    Peroxidase
    Quinolines
    Rats
    Rats, Wistar
    Tumor Necrosis Factor-alpha

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22696878