Abstract

The objective of the study is to verify effects of nebulized 3% saline hypertonic solution (HS) in comparison to normal saline (NS) in addition to epinephrine in hospitalized children with bronchiolitis. Infants were randomly assigned either to receive every 6 hours nebulized NS (group I) or 3% HS (group II) in addition to epinephrine (1.5 mg) and to conventional treatment. The main endpoints of this study were the length of stay (LOS) in hospital and the clinical response score (CSS). Patients presented a significant decrease in CSS from the first through the third day of treatment, present in the first group but even more evident in the second group (p=0.0001). Comparison between group I and II data shows significant decrease in CSS in the 3% HS-treated patients both at the second (p<0.005) and at the third day of treatment (p<0.005). Infants in the NS control group had a mean LOS of 5.6±1.6 days, whereas children treated with 3% HS were discharged with a LOS of 4.9±1.3 days, reaching a significant decrease in stay (p<0.05). In hospitalized patients bronchiolitis nebulized 3% HS and epinephrine significantly decreased symptoms and LOS as compared to 0.9% NS and epinephrine.

Authors

Miraglia Del Giudice M, Saitta F, Leonardi S, Capasso M, Niglio B, Chinellato I, Decimo F, Maiello N, Capristo C, Perrone L, Peroni D

Source

International journal of immunopathology and pharmacology 25:2 pg 485-91

MeSH

Administration, Inhalation
Adrenergic beta-Agonists
Age Factors
Bronchiolitis
Bronchodilator Agents
Epinephrine
Female
Hospitalization
Humans
Infant
Italy
Length of Stay
Linear Models
Male
Nebulizers and Vaporizers
Saline Solution, Hypertonic
Time Factors
Treatment Outcome

Pub Type(s)

Letter
Randomized Controlled Trial

Language

eng

PubMed ID

22697080