Abstract

OBJECTIVE
HbA(1c) levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. This comparison has not been performed between South Asians (SAs) and WEs. We analyzed the independent effect of ethnicity on HbA(1c) and fasting and 2-h plasma glucose (FPG and 2 hrPG, respectively) between these groups.
RESEARCH DESIGN AND METHODS
Analysis of the ADDITION-Leicester study, in which 4,688 WEs and 1,352 SAs underwent oral glucose tolerance testing, HbA(1c), and other risk factor measurements.
RESULTS
Significant associations with HbA(1c) included ethnicity, FPG, 2 hrPG, and homeostasis model assessment of β-cell function (P < 0.001); age and sex (P < 0.01); and fasting insulin and potassium (P < 0.05). After adjusting for these and other risk factors, SAs demonstrated higher HbA(1c) (6.22 and 6.02%, mean difference 0.20%, 0.10-0.30, P < 0.001), FPG (5.15 and 5.30 mmol/L, mean difference 0.15 mmol/L, 0.09-0.21, P < 0.001), and 2 hrPG (5.82 and 6.57 mmol/L, mean difference 0.75 mmol/L, 0.59-0.92, P < 0.001) compared with WEs, respectively.
CONCLUSIONS
HbA(1c), FPG, and 2 hrPG levels were higher in SAs independent of factors affecting glycemic control.

Links

Publisher Full Text

Authors

Mostafa SA, Davies MJ, Webb DR, Srinivasan BT, Gray LJ, Khunti K

Institution

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. samiul.mostafa@uhl-tr.nhs.uk

Source

Diabetes care 35:8 2012 Aug pg 1746-8

MeSH

Asian Continental Ancestry Group
Blood Glucose
European Continental Ancestry Group
Female
Glucose Tolerance Test
Hemoglobin A, Glycosylated
Humans
Male

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22699291