Independent effect of ethnicity on glycemia in South Asians and white Europeans.
HbA(1c) levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. This comparison has not been performed between South Asians (SAs) and WEs. We analyzed the independent effect of ethnicity on HbA(1c) and fasting and 2-h plasma glucose (FPG and 2 hrPG, respectively) between these groups.
RESEARCH DESIGN AND METHODS
Analysis of the ADDITION-Leicester study, in which 4,688 WEs and 1,352 SAs underwent oral glucose tolerance testing, HbA(1c), and other risk factor measurements.
Significant associations with HbA(1c) included ethnicity, FPG, 2 hrPG, and homeostasis model assessment of β-cell function (P < 0.001); age and sex (P < 0.01); and fasting insulin and potassium (P < 0.05). After adjusting for these and other risk factors, SAs demonstrated higher HbA(1c) (6.22 and 6.02%, mean difference 0.20%, 0.10-0.30, P < 0.001), FPG (5.15 and 5.30 mmol/L, mean difference 0.15 mmol/L, 0.09-0.21, P < 0.001), and 2 hrPG (5.82 and 6.57 mmol/L, mean difference 0.75 mmol/L, 0.59-0.92, P < 0.001) compared with WEs, respectively.
HbA(1c), FPG, and 2 hrPG levels were higher in SAs independent of factors affecting glycemic control.
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. email@example.com
SourceDiabetes care 35:8 2012 Aug pg 1746-8
MeSHAsian Continental Ancestry Group
European Continental Ancestry Group
Glucose Tolerance Test
Hemoglobin A, Glycosylated
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't